Lysosomal phospholipase a2 lpla2
WebGroup XV lysosomal phospholipase A2 (LPLA2 or PLA2G15) was found in the drug product of several mAb-producing cell lines at less than 1 ppm. Even at these low levels, LPLA2 was associated with the hydrolysis of PS20 and PS80. 14. The rate of polysorbate hydrolysis was shown to be both time and concentration dependent.
Lysosomal phospholipase a2 lpla2
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Web23 feb. 2024 · Here we report that this enzyme is lysosomal PLA2 (LPLA2). We show that LPLA2 is sufficient to convert PG into LPG in vitro. We show that modulating LPLA2 levels regulates BMP levels in... Web11 dec. 2014 · Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structurally uncharacterized family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport, respectively. Whereas LPLA2 is predicted to underlie the development of drug …
WebPolysorbate degrading activity was enriched from Chinese hamster ovary media leading to the identification of group XV lysosomal phospholipase A2 isomer X1 (LPLA2) by … Web1 aug. 2006 · A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine. LPLA2 is ubiquitously expressed but is most highly expressed in alveolar macrophages. Double conditional gene targeting was employed to elucidate the function of LPLA2.
WebTruncated oxidized glycerophospholipids (ox-PLs) are bioactive lipids resulting from oxidative stress. The catabolic pathways for truncated ox-PLs are not fully understood. … WebThe EnzChek® Phospholipase A2 substrate provides sensitive and continuous rapid real-time monitoring of PLA2 enzyme activities. This unique substrate is selective for PLA2 …
WebLysosomal phospholipase A2 (LPLA2) is characterized by increased activity toward zwitterionic phospholipid liposomes containing negatively charged lipids under acidic …
WebLysosomal phospholipase A2 (LPLA2) is characterized by increased activity toward zwitterionic phospholipid liposomes containing negatively charged lipids under acidic conditions. The effect of anionic lipids on … does webwatcher really workWeb1 ian. 2024 · Abstract Phospholipase A (PLA) hydrolyzes the acyl ester bonds to release fatty acids from membrane phospholipids. PLA comprises multiple families and subfamilies of enzymes that have distinct... does wechat cost moneyWebAbstract. A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and … factory snowbikeWeb8 oct. 2004 · These data suggest that elevated lysosomal phospholipase A2 is a marker of the terminally differentiated alveolar macrophage. We also evaluated the mRNA … does webuycars buy cars with swapped enginesWeb4 mar. 2024 · Lysosomal phospholipase A2 (LPLA2/PLA2G15) is a key enzyme involved in lipid homeostasis and is characterized by both phospholipase A2 and transacylase activity and by an acidic pH optimum. Divalent cations such as Ca2+ and Mg2+ have previously been shown to have little effect on the activity of LPLA2, but the discovery of … factory sneakers outletWebLysosomal phospholipase A(2) (Lpla2) is highly expressed in alveolar macrophages and may mediate the phospholipid metabolism of surfactant. Studies on the properties of this … factory snowboard brandWeb4 iun. 2024 · To evaluate the key events in hepatotoxicity associated with lysosomal phospholipase A2 (LPLA2) inhibition by cationic amphiphilic drugs (CADs), LPLA2 inhibition assays and phospholipid accumulation assays were performed in HepG2 cells. Additionally, to suggest the integrative molecular mechanisms of hepatotoxicity by CADs, … factory snowboard bindings