H1993 mutation
WebCell line H1993 was derived from the lymph nodes of a 47 year old female Caucasian with history of smoking and diagnosed with non-small cell lung cancer in 1988 (Figure 1A). After treatment with cisplatin and etoposide, H2073 was derived from the resected lung tumor of the same patient. WebJan 22, 2024 · Pitavastatin and fluvastatin induced cell death in EGFR TKI resistant NSCLC cells lines A549, Calu6 and H1993 as shown by caspase 3 activation and PARP cleavage.
H1993 mutation
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WebJun 17, 2014 · Experimental design: NCI-H1975 with EGFR-T790M mutation, NCI-H1993 with MET amplification and NCI-H460 with KRAS/PIK3CA mutation human NSCLC cells … WebNov 7, 2024 · A549, H23, H1993, and H322M cells were obtained from the National Institutes of Health, National Cancer Institute (NCI, USA). HCC-827 and H1975 cells were obtained from the American Type Culture Collection (ATCC, USA). ... In these qPCR experiments, cell lines harboring STK11 mutations (A549, H23, and H1993) displayed > …
WebApr 3, 2024 · Molecular subsets of non-small cell lung cancer (NSCLC) have been defined by various types of driver gene mutations involving epidermal growth factor receptor ( EGFR ), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog ( KRAS ), and anaplastic lymphoma kinase (ALK) gene fusion. WebErl; J, H1993-Gef or H1993-Erl) were treated with YD for 24 hr, and then miR-139-5p levels were analyzed by Taqman assay as described in the Materials and Methods. (K) Relative expression of miR-139-5p in the indicated xenografts.
http://psb.stanford.edu/psb-online/proceedings/psb14/mayba.pdf Web21 rows · Genes. 660 genes mutated in the NCI-H1993 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset. Show. Filter. Symbol. Name. ABCA12. ATP-binding cassette, sub-family A (ABC1), member 12. ABCA13.
WebCopy Number Public 22Q4 Hotspot Mutations Damaging Mutations Mutation. Compound Viability screens Drug sensitivity AUC (Sanger GDSC1) Drug sensitivity AUC (Sanger …
WebMar 1, 2007 · Notably, a somatic intronic mutation in the Met gene has been identified recently in lung cancer, resulting in a deletion in the juxtamembrane domain and … da massimilianoWebFont size indicates the frequency of mutations of each gene within this model's cancer type. Variants include both germ line predisposition variants and somatic driver mutations. Where both mutations and copy number alterations are observed in the same gene, the mutations colour coding is used. ... NCI-H1993 and NCI-H2073 were derived from the ... damassaclan letraWebApr 14, 2024 · The effect of EHE on overexpression of c-Met and EGFR in H1993 cells. The expression levels of c-Met, pMet, EGFR, and pEGFR in H1993 cells at 4 h after … marinucci dolcini gatta pdfWeb64 rows · Cancer Cell Lines with Mutant KRAS Genes. The heterogeneity of human cancers is a major obstacle to developing therapies. One way of dealing with that heterogeneity is … marinucci dolcini penaleWebNCI-H1993 [H1993] is a cell line exhibiting epithelial morphology that was isolated from the lungs of a 47-year-old, White female patient with stage 3A non-small cell lung cancer: adenocarcinoma. This product has applications in cancer research. Product category Human cells Organism Homo sapiens, human Morphology epithelial Tissue Lung Disease da massarosa a luccaWebCancer Cell Lines with Mutant KRAS Genes The heterogeneity of human cancers is a major obstacle to developing therapies. One way of dealing with that heterogeneity is to test large numbers of patient-derived cell lines for common vulnerabilities. da massa molecolare a massaWebOct 1, 2011 · EBC-1 and H1993 cell lines were previously shown to manifest high-level amplification of MET (copy number, >10). 15 Sequencing of all 21 coding exons of MET also previously revealed that H2122 cells contain an N375S mutation and that H1437 and H596 cells harbor a deletion of exon 14 of this gene. 10, 11. Growth Inhibition Assay In Vitro marinucci dolcini 2023