TīmeklisIt is noted, however, that MEK inhibitors even in combination with AKT inhibitors have not been successful in GNAQ/GNA11-mutant uveal melanomas, 44 although the biology of uveal melanoma is different than that of cutaneous melanoma. Further exploration into whether the spectrum of comutations may be driving these different outcomes is … Tīmeklis2024. gada 21. jūn. · Here, we found that MEK inhibition in uveal melanoma cells led to increased AKT and FAK signaling and that was mediated through IGF-1R and ROR receptors. Although the combination of MEK and PI3K-AKT-mTOR inhibition was suggested to be superior to MEK inhibition alone in multiple preclinical uveal …
Advances in the clinical management of uveal melanoma
TīmeklisUveal Melanoma. Uveal melanoma (UM) is the most common and aggressive primary intraocular tumor in adults. It has been estimated that the incidence of UM is about 5–6 per million people per year in America. 1,2 The incidence rate of UM increases with age and peaks at an age of 70. 3 UM is highly malignant with a mortality rate of 31% after … Tīmeklis2024. gada 2. nov. · Despite successful treatment of primary uveal melanoma, up to 50% of patients will develop systemic metastasis. Metastatic disease portends a poor outcome, and no adjuvant or metastatic therapy has been FDA approved. The genetic landscape of uveal melanoma is unique, providing prognostic and potentially … bring sb closer together
Vivian Chua - Research Instructor - Thomas Jefferson University
TīmeklisUveal melanoma is the most common primary intraocular malignancy in adults, with 4% bearing metastatic disease at presentation and nearly 50% of the patients developing metastatic disease eventually. Tīmeklis2024. gada 15. sept. · Mechanistic studies were performed to evaluate the escape pathways identified, and the efficacy of the MEK-HDAC inhibitor combination was demonstrated in multiple in vivo models of uveal melanoma. Results: We identified a number of putative escape pathways that were upregulated following MEK inhibition, … Tīmeklis2024. gada 15. aug. · Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma Clin … bring sb. back to earth