WebSemantic Scholar profile for Z. Slámová, with 25 highly influential citations and 11 scientific research papers. WebDec 23, 2024 · We propose that chromothripsis is a primary mechanism that accelerates genomic DNA rearrangement and amplification into …
Rogue versus chromothriptic cell as biomarker of cancer
Webapparent for chromothriptic Cxcr4C/o HSC in WHIM-09 could be phenocopied by non-chromothriptic mouse Cxcr4C/o HSC. We found that Cxcr4C/o bone mar-row cells are able to outcompete both wild-type (Cxcr4C/C) and WHIM (Cxcr4C/S338X) bone marrow cells after irradiation of the recipient mouse.3 Since CXCR4 mutations in WHIM patients WebChromosomal rearrangements are generally thought to accumulate gradually over many generations. However, DNA sequencing of cancer and congenital disorders uncovered a new pattern in which multiple rearrangements arise all at once. The most striking example, chromothripsis, is characterized by tens or hundreds of rearrangements confined to a … copycat recipes bang bang shrimp
Chromothripsis and cancer: causes and consequences of ... - Nature
WebAug 16, 2024 · Chromothripsis is a mitotic catastrophe that arises from multiple double strand breaks and incorrect re-joining of one or a few chromosomes. We report on … WebChromothripsis is suggested to occur in 2–3% of cancers, but in certain tumors such as osteosarcoma, it has been observed in up to 25% of samples 9,10. Chromothripsis is … WebChromothripsis is a catastrophic cellular event recently described in cancer in which chromosomes undergo massive deletion and rearrangement. Here, we report a case in which chromothripsis spontaneously cured a patient with WHIM syndrome, an autosomal dominant combined immunodeficiency disease caused by gain-of-function mutation of … copycat recipes chocolate chip cookies